Dipartimento Bio-Medico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
Intern Emerg Med. 2010 Apr;5(2):111-9. doi: 10.1007/s11739-009-0332-6. Epub 2009 Dec 9.
In this review, we have analyzed the role of visceral obesity in the occurrence of metabolic syndrome (MetS). MetS is a common metabolic disorder that has been related recently to the increasing prevalence of obesity. The disorder is defined in various ways, but in the near future a new definition(s) should be applicable worldwide. The pathophysiology has been largely attributed, in the past years, to insulin resistance, although several epidemiological and pathophysiological data now indicate visceral obesity as a main factor in the occurrence of all the components of MetS. In view of this, relationships among visceral obesity, free fatty acids, dyslipidemia and insulin resistance have been reported. In addition, the effects of some adipocytokines and other proinflammatory factors produced by fat accumulation on the occurrence of MetS have been also emphasized. Accordingly, the "hypoadiponectinemia hypothesis" has been proposed as the most interesting to explain the pathophysiology of MetS. The epidemiologic, pathophysiologic and clinical data reported seem to indicate that MetS might be considered a fatal consequence of visceral obesity.
在这篇综述中，我们分析了内脏肥胖在代谢综合征（MetS）发生中的作用。MetS 是一种常见的代谢紊乱，近年来与肥胖症的发病率上升有关。该疾病有多种定义，但在不久的将来，一种新的定义（多个定义）应该适用于全世界。在过去的几年中，尽管一些流行病学和病理生理学数据现在表明内脏肥胖是 MetS 所有成分发生的主要因素，但胰岛素抵抗在很大程度上被归因于其病理生理学。有鉴于此，已经报道了内脏肥胖、游离脂肪酸、血脂异常和胰岛素抵抗之间的关系。此外，还强调了脂肪堆积产生的一些脂肪细胞因子和其他促炎因子对 MetS 发生的影响。因此，提出了“低脂联素血症假说”，以解释 MetS 的病理生理学。报告的流行病学、病理生理学和临床数据似乎表明，MetS 可能被认为是内脏肥胖的致命后果。
