Ivanova A S, Arkhipova O G, Kupina L M, Pavlovskaia L V
Vopr Med Khim. 1980 Sep-Oct;26(5):595-8.
Development of silicosis was accompanied by phase alterations in lipid peroxidation, manifested as a distinct increase at the early steps of the hydroperoxides content in lungs with their subsequent decrease below the normal level. The antioxidative activity of lipids, contrary to hydroperoxide content, was decreased at early steps and then it was increased 3.5-fold above the normal level. An interrelationship between the antioxidative activity and composition of phospholipids was found; content of phosphatidylcholine and sphingomyelin was markedly increased at early steps. The correlation observed between lipid peroxidation, composition of phospholipids and the activity of the lipid-dependent enzymes suggest an importance of impairments in lipid peroxidation for pathogenesis of silicosis.
矽肺的发展伴随着脂质过氧化的阶段性变化，表现为肺中氢过氧化物含量在早期明显增加，随后降至正常水平以下。与氢过氧化物含量相反，脂质的抗氧化活性在早期降低，然后增加至高于正常水平3.5倍。发现抗氧化活性与磷脂组成之间存在相互关系；早期磷脂酰胆碱和鞘磷脂的含量明显增加。脂质过氧化、磷脂组成与脂质依赖性酶活性之间的相关性表明脂质过氧化损伤在矽肺发病机制中具有重要意义。
