用二氢还原双(二硫代烯)氧(二硫代)钨(VI)配合物与来自 Pyrococcus furiosus 的第四种含钨酶 (WOR4) 的化学功能有关。
Reduction of bis(dithiolene)oxo(disulfido)tungsten(VI) complex with dihydrogen related to the chemical function of the fourth tungsten-containing enzyme (WOR4) from Pyrococcus furiosus.
机构信息
Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
出版信息
J Am Chem Soc. 2010 Jan 13;132(1):8-9. doi: 10.1021/ja907164s.
Sulfurization of five-coordinate W(IV)O(1,2-benzenedithiolate)(2) proceeds under very mild conditions to form seven-coordinate W(VI)O(eta(2)-S(2))(1,2-benzenedithiolate)(2), from which H(2)S was generated by treatment with H(2). This is the first functional model for the fourth tungsten-containing WOR4 enzyme. Kinetics and isotope-scrambling experiments have suggested the existence of six-coordinate W(V)(eta(1)-S(2)) species as a key reaction intermediate.
五配位W(IV)O(1,2-苯二硫醇)(2)在非常温和的条件下进行硫化反应，形成七配位W(VI)O(η(2)-S(2))(1,2-苯二硫醇)(2)，后者与 H(2)反应生成 H(2)S。这是第四个含钨 WOR4 酶的第一个功能模型。动力学和同位素混合实验表明，六配位 W(V)(η(1)-S(2))物种作为关键反应中间体存在。
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