在环境条件下的氧气活化：Cu 催化的末端炔烃的氧化氨化-二酮化反应，生成α-酮酰胺。
Dioxygen activation under ambient conditions: Cu-catalyzed oxidative amidation-diketonization of terminal alkynes leading to alpha-ketoamides.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
出版信息
J Am Chem Soc. 2010 Jan 13;132(1):28-9. doi: 10.1021/ja908911n.
PMID:20000433
Abstract
A novel Cu-catalyzed oxidative amidation-diketonization reaction of terminal alkynes leading to alpha-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O(2) not only participates as the ideal oxidant but also undergoes dioxygen activation under ambient conditions in this transformation.
摘要
发展了一种新型的 Cu 催化末端炔烃的氧化酰胺化-二酮化反应，生成α-酮酰胺。这种化学通过自由基过程为这种新型的 Cu 催化提供了有价值的机理见解。在这种转化中，O(2)不仅作为理想的氧化剂参与，而且在环境条件下经历双氧活化。
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