新型含 1,4-二氢吡啶骨架的烟碱类似物的设计、多组分合成及生物活性。
Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold.
机构信息
Shanghai Key Laboratory of Chemistry Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai, China 200237.
出版信息
J Agric Food Chem. 2010 Mar 10;58(5):2741-5. doi: 10.1021/jf902034z.
Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance pi-pi stacking. The synthesized compounds were identified by (1)H NMR, (13)C NMR, high-resolution mass spectroscopy, and elemental analysis. Bioassay tests showed that some of them exhibited high insecticidal activities against pea aphid ( Aphis craccivora ).
新型含 1,4-二氢吡啶骨架的烟碱类似物通过多组分反应 (MCRs) 设计和合成，以增强 π-π 堆积。通过 (1)H NMR、(13)C NMR、高分辨率质谱和元素分析鉴定了合成的化合物。生物测定试验表明，其中一些化合物对豌豆蚜 (Aphis craccivora) 具有高杀虫活性。
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