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1,4 - 二氢吡啶：合成进展、药用及杀虫特性

1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties.

作者信息

A Parthiban, Makam Parameshwar

机构信息

Centre for Excellence on GMP Extraction Facility, National Institute of Pharmaceutical Education and Research, (NIPER) Guwahati Assam India 781101.

Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University Arcadia Grant, P. O. Chandanwari, Premnagar Dehradun Uttarakhand India 248007

出版信息

RSC Adv. 2022 Oct 12;12(45):29253-29290. doi: 10.1039/d2ra04589c. eCollection 2022 Oct 11.

DOI:10.1039/d2ra04589c
PMID:36320730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9555063/
Abstract

1,4-Dihydropyridine (1,4-DHP) is one of the foremost notable organic scaffolds with diverse pharmaceutical applications. This study will highlight recent accomplishments in the construction of 1,4-DHP with structural and functional modifications using multi-component one-pot and green synthetic methodologies. The various intrinsic therapeutic applications, ranging from calcium channel blocker, anti-oxidative, anticancer, anti-inflammatory, anti-microbial, anti-hypertensive, anti-diabetic, anticoagulants, anti-cholinesterase, neuro-protective, and other miscellaneous activities, have been summarized with a focus on their structure-activity relationship (SAR) investigations. In addition, the insecticidal properties have been collated and discussed. Researchers in the fields of medicinal chemistry and drug development will find the summarized conclusions of this study incredibly informative, instructional, and valuable.

摘要

1,4-二氢吡啶（1,4-DHP）是一种具有多种药物应用的最重要的有机骨架之一。本研究将重点介绍使用多组分一锅法和绿色合成方法构建具有结构和功能修饰的1,4-DHP的最新成果。总结了其各种内在治疗应用，包括钙通道阻滞剂、抗氧化、抗癌、抗炎、抗菌、抗高血压、抗糖尿病、抗凝、抗胆碱酯酶、神经保护及其他杂项活性，并重点关注其构效关系（SAR）研究。此外，还整理并讨论了其杀虫特性。药物化学和药物开发领域的研究人员会发现本研究的总结结论极具信息性、指导性和价值。

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