用于治疗和免疫治疗中药物、基因及细胞递送的靶向微泡

Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.

作者信息

Navarro-Becerra J Angel, Borden Mark A

机构信息

Mechanical Engineering Department, University of Colorado Boulder, Boulder, CO 80309, USA.

Biomedical Engineering Program, University of Colorado Boulder, Boulder, CO 80309, USA.

出版信息

Pharmaceutics. 2023 May 30;15(6):1625. doi: 10.3390/pharmaceutics15061625.

DOI:10.3390/pharmaceutics15061625

PMID:37376072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10302530/

Abstract

Microbubbles are 1-10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through bioconjugation of a ligand, drug and/or cell. Since their inception a few decades ago, several targeted microbubble (tMB) formulations have been developed as ultrasound imaging probes and ultrasound-responsive carriers to promote the local delivery and uptake of a wide variety of drugs, genes, and cells in different therapeutic applications. The aim of this review is to summarize the state-of-the-art of current tMB formulations and their ultrasound-targeted delivery applications. We provide an overview of different carriers used to increase drug loading capacity and different targeting strategies that can be used to enhance local delivery, potentiate therapeutic efficacy, and minimize side effects. Additionally, future directions are proposed to improve the tMB performance in diagnostic and therapeutic applications.

摘要

微泡是直径为1-10μm的充有气体的声学活性颗粒，通常由磷脂单分子层壳稳定。微泡可以通过配体、药物和/或细胞的生物偶联进行工程改造。自几十年前问世以来，已经开发了几种靶向微泡（tMB）制剂，作为超声成像探针和超声响应载体，以促进多种药物、基因和细胞在不同治疗应用中的局部递送和摄取。本综述的目的是总结当前tMB制剂的最新技术及其超声靶向递送应用。我们概述了用于提高药物负载能力的不同载体以及可用于增强局部递送、提高治疗效果和最小化副作用的不同靶向策略。此外，还提出了未来的发展方向，以改善tMB在诊断和治疗应用中的性能。