Bell Heather C, McCaffrey David R, Forgie Margaret L, Kolb Bryan, Pellis Sergio M
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada.
Behav Neurosci. 2009 Dec;123(6):1158-68. doi: 10.1037/a0017617.
Although decorticated rats are able to engage in play, their play is abnormal in three ways. First, decorticates do not display the normal, age-related shifts in defensive strategies during development. Second, decorticates do not modify their defensive tactics in response to the social identity of their partners. Third, decorticates display a global shift in defensive tactics from more complex to less complex strategies. It has been shown that lesions of the motor cortex (MC) selectively produce the abnormal developmental effects on play, and that lesions of the orbitofrontal cortex (OFC) selectively produce the deficits in behavioral discrimination between social partners. In the current set of experiments, we demonstrate that lesions of the medial prefrontal cortex (mPFC) produce the shift from more complex to less complex defensive tactics, while leaving intact the age-related and partner-related modulation of defensive strategies. Thus, we have evidence for a triple dissociation of function between the MC, the OFC, and the mPFC with respect to social play behavior.
虽然去皮质大鼠能够玩耍，但它们的玩耍在三个方面是异常的。首先，去皮质大鼠在发育过程中不会表现出与年龄相关的正常防御策略转变。其次，去皮质大鼠不会根据其伙伴的社会身份来调整其防御策略。第三，去皮质大鼠的防御策略从更复杂的策略整体转变为不太复杂的策略。研究表明，运动皮层（MC）损伤会选择性地对玩耍产生异常的发育影响，而眶额叶皮层（OFC）损伤会选择性地导致在区分社会伙伴行为方面出现缺陷。在当前这组实验中，我们证明内侧前额叶皮层（mPFC）损伤会导致从更复杂的防御策略转变为不太复杂的防御策略，同时保持与年龄相关和与伙伴相关的防御策略调节功能完好。因此，我们有证据表明，在社会玩耍行为方面，MC、OFC和mPFC之间存在功能的三重分离。
