系统性红斑狼疮中反应性中间产物的生物学。
The biology of reactive intermediates in systemic lupus erythematosus.
机构信息
Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC 29425, USA.
出版信息
Autoimmunity. 2010 Feb;43(1):56-63. doi: 10.3109/08916930903374683.
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune syndrome marked by autoantibody production. Innate immunity is essential to transform humoral autoimmunity into the clinical lupus phenotype. Nitric oxide (NO) is a membrane- permeable signaling molecule involved in a broad array of biologic processes through its ability to modify proteins, lipids, and DNA and alter their function and immunogenicity. The literature regarding mechanisms through which NO regulates inflammation and cell survival is filled with contradictory findings. However, the effects of NO on cellular processes depend on its concentration and its interaction with reactive oxygen. Understanding this interaction will be essential to determine mechanisms through which reactive intermediates induce cellular autoimmunity and contribute to a sustained innate immune response and organ damage in SLE.
摘要
系统性红斑狼疮（SLE）是一种自身免疫综合征，其特征是自身抗体的产生。先天免疫对于将体液自身免疫转化为临床狼疮表型至关重要。一氧化氮（NO）是一种膜通透的信号分子，通过修饰蛋白质、脂质和 DNA 及其功能和免疫原性，参与广泛的生物学过程。关于 NO 调节炎症和细胞存活的机制的文献充满了相互矛盾的发现。然而，NO 对细胞过程的影响取决于其浓度及其与活性氧的相互作用。理解这种相互作用对于确定活性中间体如何诱导细胞自身免疫以及如何导致 SLE 中持续的先天免疫反应和器官损伤的机制至关重要。
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