Kim Jong Hun, Choi Min Sik
Department of Food Science and Biotechnology, and Institute for Basic Sciences, Sungshin Women's University, Seoul 01133, Republic of Korea.
Lab of Pharmacology, College of Pharmacy, Dongduk Women's University, Seoul 02748, Republic of Korea.
Biomol Ther (Seoul). 2023 Jul 1;31(4):388-394. doi: 10.4062/biomolther.2023.101. Epub 2023 Jun 22.
Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functions such as vasodilation, pigmentation, hair growth, wound healing, and immune responses. NO modulates both innate and adaptive immune responses. As a signaling molecule and cytotoxic effector, NO influences the function of immune cells and production of cytokines. NO is a key mediator that protects against or contributes to skin inflammation. Moreover, NO has been implicated in skin sensitization, a process underlying contact dermatitis. It modulates the function of dendritic cells and T cells, thereby affecting the immune response to allergens. NO also plays a role in contact dermatitis by inducing inflammation and tissue damage. NO-related chemicals, such as nitrofatty acids and nitric oxide synthase (NOS) inhibitors, have potential therapeutic applications in skin conditions, including allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). Further research is required to fully elucidate the therapeutic potential of NO-related chemicals and develop personalized treatment strategies for skin conditions.
一氧化氮（NO）是一种信号分子，在众多细胞生理过程中发挥着关键作用。在皮肤中，角质形成细胞、成纤维细胞、内皮细胞和免疫细胞均可产生NO，它参与血管舒张、色素沉着、毛发生长、伤口愈合及免疫反应等皮肤功能。NO可调节先天性和适应性免疫反应。作为一种信号分子和细胞毒性效应物，NO影响免疫细胞的功能和细胞因子的产生。NO是预防或引发皮肤炎症的关键介质。此外，NO与皮肤致敏有关，这是接触性皮炎的潜在发病机制。它调节树突状细胞和T细胞的功能，从而影响对过敏原的免疫反应。NO还通过诱导炎症和组织损伤在接触性皮炎中发挥作用。与NO相关的化学物质，如硝基脂肪酸和一氧化氮合酶（NOS）抑制剂，在包括过敏性接触性皮炎（ACD）和刺激性接触性皮炎（ICD）在内的皮肤疾病中具有潜在的治疗应用价值。需要进一步研究以充分阐明与NO相关化学物质的治疗潜力，并为皮肤疾病制定个性化的治疗策略。
