重型地中海贫血的心脏并发症
Cardiac complications in thalassemia major.
作者信息
Wood John C
机构信息
Division of Cardiology, Children's Heart Center, Children's Hospital of Los Angeles, Los Angeles, CA 90027-0034, USA.
出版信息
Hemoglobin. 2009;33 Suppl 1(Suppl 1):S81-6. doi: 10.3109/03630260903347526.
Abstract
Thalassemia major is characterized by chronic ineffective erythropoiesis and anemia as its primary problems. These, in turn, produce physiologic adaptations in the cardiovascular system as well as pathologic/iatrogenic processes such as iron overload, splenectomy, nutritional deficiencies, chronic oxidative stress, and lung disease. This article discusses the pathophysiology of thalassemia as it relates to the cardiovascular system, the mechanisms and monitoring of iron cardiomyopathy, pulmonary hypertension, and vascular aging in thalassemia patients.
摘要
重型地中海贫血的主要特征是慢性无效红细胞生成和贫血。这些问题进而会在心血管系统中产生生理适应性变化，以及引发诸如铁过载、脾切除术、营养缺乏、慢性氧化应激和肺部疾病等病理/医源性过程。本文讨论了地中海贫血与心血管系统相关的病理生理学、铁性心肌病的机制和监测、地中海贫血患者的肺动脉高压和血管老化。
相似文献
1
Cardiac complications in thalassemia major.
Hemoglobin. 2009;33 Suppl 1(Suppl 1):S81-6. doi: 10.3109/03630260903347526.
2
Heart disease in thalassemia intermedia: a review of the underlying pathophysiology.
Haematologica. 2007 May;92(5):658-65. doi: 10.3324/haematol.10915.
3
Cardiac complications in thalassemia throughout the lifespan: Victories and challenges.
Ann N Y Acad Sci. 2023 Dec;1530(1):64-73. doi: 10.1111/nyas.15078. Epub 2023 Oct 30.
4
Cardiac complications in beta-thalassemia: From mice to men.
Exp Biol Med (Maywood). 2017 Jun;242(11):1126-1135. doi: 10.1177/1535370217708977. Epub 2017 May 9.
5
Beta-thalassemia cardiomyopathy: history, present considerations, and future perspectives.
Circ Heart Fail. 2010 May;3(3):451-8. doi: 10.1161/CIRCHEARTFAILURE.109.913863.
6
Treatment of cardiac iron overload in thalassemia major.
Haematologica. 2003 May;88(5):481-2.
7
RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β-thalassemia intermedia.
Am J Hematol. 2018 Jun;93(6):745-750. doi: 10.1002/ajh.25079. Epub 2018 Mar 23.
8
Evidence for a novel mechanism independent of myocardial iron in β-thalassemia cardiac pathogenesis.
PLoS One. 2012;7(12):e52128. doi: 10.1371/journal.pone.0052128. Epub 2012 Dec 17.
9
Cardiac complications and iron overload in beta thalassemia major patients-a systematic review and meta-analysis.
Ann Hematol. 2019 Jun;98(6):1323-1331. doi: 10.1007/s00277-019-03618-w. Epub 2019 Feb 7.
10
β-Thalassemia intermedia: a comprehensive overview and novel approaches.
Int J Hematol. 2018 Jul;108(1):5-21. doi: 10.1007/s12185-018-2411-9. Epub 2018 Jan 29.
引用本文的文献
1
Correlation between vitamin D level and left ventricular myocardial function demonstrated by speckle tracking echocardiography among β-thalassemia major children.
Eur J Pediatr. 2025 Jun 16;184(7):420. doi: 10.1007/s00431-025-06250-1.
2
Prevalence and Correlates of Dilated and Non-Dilated Left Ventricular Cardiomyopathy in Transfusion-Dependent Thalassemia: Data from a National, Multicenter, Observational Registry.
J Cardiovasc Dev Dis. 2025 Mar 16;12(3):103. doi: 10.3390/jcdd12030103.
3
Relationship between hemoglobinopathies and male infertility: a scoping review.
Int J Hematol. 2024 Nov;120(5):566-574. doi: 10.1007/s12185-024-03844-7. Epub 2024 Sep 27.
4
Diagnostic Modalities in Detecting Cardiovascular Complications of Thalassemia.
Rev Cardiovasc Med. 2022 Jul 22;23(8):267. doi: 10.31083/j.rcm2308267. eCollection 2022 Aug.
5
Cardiac complications in thalassemia throughout the lifespan: Victories and challenges.
Ann N Y Acad Sci. 2023 Dec;1530(1):64-73. doi: 10.1111/nyas.15078. Epub 2023 Oct 30.
6
Complications in patients with transfusion dependent thalassemia: A descriptive cross-sectional study.
Health Sci Rep. 2023 Oct 11;6(10):e1624. doi: 10.1002/hsr2.1624. eCollection 2023 Oct.
7
The relationship of myocardial and liver T2* values with cardiac function and laboratory findings in transfusion-dependent thalassemia major patients: A retrospective cardiac MRI study.
J Cardiovasc Thorac Res. 2023;15(2):86-92. doi: 10.34172/jcvtr.2023.31592. Epub 2023 Jun 29.
8
Frontal Plane QRS-T Angle as a Marker of Cardiac Iron Overload in Patients with Beta Thalassemia Major.
Acta Cardiol Sin. 2023 May;39(3):406-415. doi: 10.6515/ACS.202305_39(3).20221114B.
9
Multi-Parametric Cardiac Magnetic Resonance for Prediction of Heart Failure Death in Thalassemia Major.
Diagnostics (Basel). 2023 Feb 26;13(5):890. doi: 10.3390/diagnostics13050890.
10
Left ventricular global function index is associated with myocardial iron overload and heart failure in thalassemia major patients.
Int J Cardiovasc Imaging. 2023 May;39(5):991-999. doi: 10.1007/s10554-023-02792-3. Epub 2023 Jan 13.
本文引用的文献
1
Nutritional deficiencies in iron overloaded patients with hemoglobinopathies.
Am J Hematol. 2009 Jun;84(6):344-8. doi: 10.1002/ajh.21416.
2
Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major.
Br J Haematol. 2008 Jun;141(6):891-4. doi: 10.1111/j.1365-2141.2008.07135.x. Epub 2008 Mar 26.
3
Global vasomotor dysfunction and accelerated vascular aging in beta-thalassemia major.
Atherosclerosis. 2008 Jun;198(2):448-57. doi: 10.1016/j.atherosclerosis.2007.09.030. Epub 2007 Nov 7.
4
Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron.
J Magn Reson Imaging. 2007 Jun;25(6):1147-51. doi: 10.1002/jmri.20915.
5
Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state.
Am J Hematol. 2006 Sep;81(9):670-5. doi: 10.1002/ajh.20640.
6
Physiology and pathophysiology of iron cardiomyopathy in thalassemia.
Ann N Y Acad Sci. 2005;1054:386-95. doi: 10.1196/annals.1345.047.
7
Improvement of cardiac function in thalassemia major treated with L-carnitine.
Acta Haematol. 2004;111(3):143-8. doi: 10.1159/000076522.
Zotero 插件