Gynecologic Oncology, New York University School of Medicine, New York, NY, USA.
Future Oncol. 2009 Dec;5(10):1659-73. doi: 10.2217/fon.09.120.
Lysophosphatidic acid (LPA), a bioactive phospholipid, stimulates survival, proliferation, adhesion, migration and invasion of ovarian cancer cells through the activation of G-protein-coupled plasma membrane receptors. LPA and its receptors are aberrantly expressed in ovarian cancer, with high levels predominantly found in malignant ascites and in the plasma of ovarian cancer patients. LPA signals multiple intracellular pathways, such as Ras/MEKK1-MAPK and PI3K/Akt, to promote growth factors and protease expression, and induce angiogenesis and tumor cell invasion through the extracellular matrix and across the basement membrane. Only a small portion of this intricate lipid-signaling cascade has been characterized thus far. We believe that elucidation of this complex transduction network will provide further opportunities to understand the mechanism of ovarian carcinogenesis, invasion and metastasis.
溶血磷脂酸（LPA）是一种生物活性磷脂，通过激活 G 蛋白偶联的质膜受体，刺激卵巢癌细胞的存活、增殖、黏附、迁移和侵袭。LPA 和其受体在卵巢癌中异常表达，高水平主要存在于恶性腹水和卵巢癌患者的血浆中。LPA 信号转导多种细胞内途径，如 Ras/MEKK1-MAPK 和 PI3K/Akt，促进生长因子和蛋白酶的表达，并通过细胞外基质和基底膜诱导血管生成和肿瘤细胞侵袭。迄今为止，只有这一复杂的脂质信号级联反应的一小部分得到了描述。我们相信，阐明这一复杂的转导网络将为进一步了解卵巢癌发生、侵袭和转移的机制提供机会。
