PTEN 缺失在人类肿瘤中的作用机制表明了潜在的治疗机会。
The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities.
机构信息
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Biomolecules. 2019 Nov 7;9(11):713. doi: 10.3390/biom9110713.
Abstract
In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.
摘要
在这篇综述中，我们首先将简要描述与癌症中 PTEN 功能丧失相关的多种分子机制。然后，我们将继续讨论将 PTEN 缺失与 PI3K 激活联系起来的分子机制，并展示这些机制如何为 PTEN 缺失肿瘤患者提供可能的治疗方法。
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