Shokida Felisa, Eleta Martin, Sidelnik Mariano, Gabriel Jose
Department of Ophthalmology, Hoapital Italiano, Buenos Aires, Argentina.
Binocul Vis Strabismus Q. 2009;24(4):222-7.
The aim of this study was to determine if patients with strabismic amblyopia could have increased occipital visual cortex activation with monocular stimulation of the sound fixing eye, rather than with simultaneous stimulation of both eyes.
A prospective study was performed including 12 patients with strabismus and amblyopia, who were evaluated using functional MRI with visual stimulation paradigms. The measurements were made in the occipital visual cortex, assessing the response to the binocular and monocular stimulation.
12 out of 12 patients showed an increased cortical response of the healthy eye in comparison to the amblyopic one. Nine of the 12 patients showed larger cortical activation with visual stimulation of the healthy eye compared to the binocular condition analysis. Three out of the 12 cases had a greater activation area when the stimulation was binocular rather than monocular, 2 of whom had a relatively small angle of strabismus.
Patients with amblyopia and strabismus could see better with only one eye instead of both eyes. This could be related to inhibition of the binocular function of the brain by the misaligned amblyopic eye.
本研究的目的是确定患有斜视性弱视的患者在单眼刺激注视眼时，而非双眼同时刺激时，枕叶视觉皮层的激活是否会增加。
进行了一项前瞻性研究，纳入12例斜视性弱视患者，使用功能性磁共振成像和视觉刺激范式对其进行评估。测量在枕叶视觉皮层进行，评估对双眼和单眼刺激的反应。
12例患者中，12例均显示健康眼的皮层反应相较于弱视眼有所增加。12例患者中有9例在单眼刺激健康眼时比双眼条件分析时显示出更大的皮层激活。12例中有3例在双眼刺激而非单眼刺激时激活面积更大，其中2例斜视角度相对较小。
患有弱视和斜视的患者单眼视物比双眼视物更好。这可能与弱视眼的斜视导致大脑双眼功能受到抑制有关。
