Abasova L I, Babaev A M, Shiralieva R K
Kardiologiia. 2009;49(11):51-5.
In this review we systematized literature data illuminating problems of prevention and correction of cognitive disorders in patients with arterial hypertension (AH). On the basis of results of multicenter randomized studies we have demonstrated close interrelationship between cardiac and cerebral pathology and value of treatment of concomitant neurologic and cardiovascular disorders for prevention of cognitive disturbances in patients with AH. We have shown rational approach to planning antihypertensive therapy and to degree of arterial pressure (AP) lowering in patients with AH, including those with cerebrovascular pathology having high risk of development of stroke and dementia. It has been also shown that in patients with AH calcium antagonists, angiotensin II receptor blockers, and inhibitors of angiotensin converting enzyme posses definite advantages over antihypertensive drugs from other classes in prevention of dementia and less severe cognitive disturbances.
在本综述中,我们对阐明动脉高血压(AH)患者认知障碍预防和纠正问题的文献数据进行了系统化整理。基于多中心随机研究的结果,我们证明了心脏和脑部病理之间的密切相互关系,以及治疗伴发的神经和心血管疾病对于预防AH患者认知障碍的价值。我们展示了针对AH患者制定合理的抗高血压治疗方案以及降低动脉血压(AP)程度的方法,包括那些患有脑血管疾病且有中风和痴呆高发病风险的患者。还表明,在AH患者中,钙拮抗剂、血管紧张素II受体阻滞剂和血管紧张素转换酶抑制剂在预防痴呆和较轻微认知障碍方面比其他类别的抗高血压药物具有一定优势。