Sellheyer Klaus, Krahl Dieter
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA.
J Cutan Pathol. 2010 Jun;37(6):624-34. doi: 10.1111/j.1600-0560.2009.01477.x. Epub 2009 Dec 1.
Stem cell biology is currently making its impact on medicine, which will probably increase over the next decades. It not only influences our therapeutic thinking caused by the enormous plasticity of stem cells but also affects diagnostic and conceptual aspects of dermatopathology. Although our knowledge of the keratinocytic stem cells located within the follicular bulge has exploded exponentially since their discovery in 1990, the concept of cutaneous mesenchymal stem cells (MSCs) is new. Described initially in 2001 in mice, MSCs later were also found in the human dermis. The connective tissue sheath and the papilla of the hair follicle probably represent the anatomical niche for cutaneous MSCs. In line with the cancer stem cell hypothesis, mutations of these cells may be the underlying basis of mesenchymal skin neoplasms, such as dermatofibrosarcoma protuberans. Furthermore, research on cutaneous MSCs may impact our thinking on the interaction of the epithelial component of skin neoplasms with their surrounding stroma. We are only in the early stages to recognize the importance of the potential contributions of cutaneous MSC research to dermatopathology, but it is not inconceivable to assume that they could be tremendous, paralleling the early discovery of the follicular bulge as a stem cell niche.
干细胞生物学目前正在对医学产生影响，在未来几十年这种影响可能会增强。它不仅因干细胞的巨大可塑性影响着我们的治疗思路，还影响着皮肤病理学的诊断和概念方面。尽管自1990年发现毛囊隆突内的角质形成干细胞以来，我们对其的了解呈指数级增长，但皮肤间充质干细胞（MSC）的概念却是新的。MSC最初于2001年在小鼠中被描述，后来在人类真皮中也被发现。毛囊的结缔组织鞘和乳头可能是皮肤MSC的解剖学微环境。与癌症干细胞假说一致，这些细胞的突变可能是间质性皮肤肿瘤（如隆突性皮肤纤维肉瘤）的潜在基础。此外，对皮肤MSC的研究可能会影响我们对皮肤肿瘤上皮成分与其周围基质相互作用的看法。我们才刚刚开始认识到皮肤MSC研究对皮肤病理学潜在贡献的重要性，但可以想象这种贡献可能是巨大的，这与毛囊隆突作为干细胞微环境的早期发现相类似。
