Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zürich, Winterthurerstr 260, 8057 Zürich, Switzerland.
J Vet Intern Med. 2010 Jan-Feb;24(1):120-6. doi: 10.1111/j.1939-1676.2009.0425.x.
The Guardian REAL-Time is a continuous glucose-monitoring system (CGMS) recently developed to provide instantaneous interstitial glucose concentrations; the system does not require a monitor being fixed to the animal.
The CGMS provides accurate and reproducible real-time readings of glucose concentration in cats.
Thirty-two diabetic cats, 2 cats with suspected insulinoma, and 5 healthy cats.
Prospective, observational study. CGMS accuracy was compared with a reference glucose meter at normal, high, and low blood glucose concentrations using error grid analysis. Reading variability of 2 simultaneously used CGMS was determined in diabetic cats by calculating correlation and percentage of concordance of paired data at different glycemic ranges. The time interval between increasing glycemia and a rise in interstitial fluid glucose measured by the CGMS was assessed in healthy cats receiving glucose IV; the time point of maximal increase in interstitial glucose concentrations was calculated.
The CGMS was 100, 96.1, and 91.0% accurate at normal, high, and low blood glucose concentrations. Measurements deviated from reference by -12.7 +/- 70.5 mg/dL at normal, -12.1 +/- 141.5 mg/dL at high, and -1.9 +/- 40.9 mg/dL at low glucose concentrations. Overall, paired CGMS readings correlated significantly (r = 0.95, P < .0001) and concordance was 95.7%. The median delay after IV administration of glucose to an increase in interstitial glucose was 11.4 minutes (range: 8.8-19.7 minutes).
Although some readings substantially deviated from reference values, the CGMS yields reproducible results, is clinically accurate in cats with hyperglycemia and euglycemia, and is slightly less accurate if blood glucose concentrations are low. Rapidly increasing interstitial glucose after a glycemic rise suggests that the CGMS is suitable for real-time measurement under clinical conditions.
Guardian REAL-Time 是一种新开发的连续血糖监测系统（CGMS），用于提供即时的间质葡萄糖浓度；该系统不需要将监测器固定在动物身上。
CGMS 能提供准确且可重复的猫血糖浓度实时读数。
32 只糖尿病猫、2 只疑似胰岛素瘤猫和 5 只健康猫。
前瞻性、观察性研究。通过误差网格分析，比较 CGMS 在正常、高、低血糖浓度下与参考血糖仪的准确性。在不同血糖范围内，通过计算相关系数和一致性百分比，确定同时使用 2 个 CGMS 的糖尿病猫的读数可变性。在接受静脉注射葡萄糖的健康猫中，评估血糖升高与 CGMS 测量的间质液葡萄糖升高之间的时间间隔；计算间质葡萄糖浓度达到最大值的时间点。
CGMS 在正常、高、低血糖浓度下的准确性分别为 100%、96.1%和 91.0%。在正常血糖浓度下，测量值偏离参考值 -12.7 ± 70.5mg/dL，在高血糖浓度下 -12.1 ± 141.5mg/dL，在低血糖浓度下 -1.9 ± 40.9mg/dL。总体而言，配对 CGMS 读数具有显著相关性（r = 0.95，P<.0001），一致性为 95.7%。静脉注射葡萄糖后间质葡萄糖增加的中位延迟时间为 11.4 分钟（范围：8.8-19.7 分钟）。
尽管一些读数与参考值有较大偏差，但 CGMS 可提供可重复的结果，在高血糖和血糖正常的猫中具有临床准确性，而在血糖浓度较低时准确性略低。血糖升高后间质葡萄糖快速增加表明 CGMS 适用于临床条件下的实时测量。
