Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
J Viral Hepat. 2010 Apr;17(4):229-35. doi: 10.1111/j.1365-2893.2009.01193.x. Epub 2009 Nov 30.
The pathogenesis of hepatitis B virus (HBV) is complex and it appears that molecular variants play a role in this process. HBV undergoes numerous rounds of error prone production within an infected host. The resulting quasispecies are heterogeneous and in the absence of archaeological records of past infection, the evolution of HBV can only be inferred indirectly from its epidemiology and by genetic analysis. This review gathered the controversies about the HBV origin and factors influencing its quasispecies. Also, it provided some evidence on how HBV genotypes correlated with human history and patterns of migration. It is our belief that this topic deserves further attention and thus it is likely that more critical research work will be performed to elucidate the unknown mechanisms and processes in this area.
乙型肝炎病毒 (HBV) 的发病机制复杂，分子变异似乎在此过程中起作用。HBV 在受感染的宿主中经历多次易错产生。由此产生的准种是异质的，在没有过去感染的考古记录的情况下，只能通过其流行病学和遗传分析间接推断 HBV 的进化。本综述收集了关于 HBV 起源和影响其准种形成的因素的争议。此外，还提供了一些证据，说明 HBV 基因型如何与人类历史和迁移模式相关联。我们相信这个主题值得进一步关注，因此很可能会有更多的批判性研究工作来阐明该领域的未知机制和过程。
