大鼠声带黏膜损伤后细胞形态、密度和分布的改变。
Alteration in cellular morphology, density and distribution in rat vocal fold mucosa following injury.
机构信息
Department of Surgery, Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA.
出版信息
Wound Repair Regen. 2010 Jan-Feb;18(1):89-97. doi: 10.1111/j.1524-475X.2009.00550.x. Epub 2009 Dec 11.
The vocal fold mucosa plays an important role in voice production. Its cellular composition and density frequently change under various pathological conditions, often contributing to altered extracellular matrix production, tissue viscoelasticity, and voice quality. In this study, cellular changes in the rat mucosa following a unilateral stripping injury were investigated and analyzed semi-quantitatively. Distinctive and sequential changes in cellular morphology, composition, and density were observed in the mucosa post-injury. Cellular recruitment was a major event during the early stage of injury and reached its peak level by day 5 post-injury. Several types of cells, including neutrophil-like cells, epithelial cells, and fibroblast-like cells, were sequentially recruited. The sequential emergence of reactive cell populations following injury and subsequent reconstruction of the mucosa suggests their involvement in vocal fold tissue repair and scar formation processes.
声带黏膜在发声中起着重要作用。在各种病理条件下，其细胞组成和密度经常发生变化，这常常导致细胞外基质产生、组织粘弹性和音质改变。在这项研究中，研究了单侧剥脱损伤后大鼠黏膜中的细胞变化，并进行了半定量分析。损伤后观察到黏膜中细胞形态、组成和密度的明显和连续变化。细胞募集是损伤早期的主要事件，到损伤后第 5 天达到高峰水平。几种类型的细胞，包括类中性粒细胞细胞、上皮细胞和成纤维细胞样细胞，依次被募集。损伤后反应性细胞群的顺序出现以及随后的黏膜重建表明它们参与了声带组织修复和瘢痕形成过程。
Zotero 插件