Department of Pathology and Laboratory Medicine, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19105, USA.
Transfusion. 2010 Apr;50(4):875-80. doi: 10.1111/j.1537-2995.2009.02530.x. Epub 2009 Dec 10.
Travelers returning to the United States from malaria-endemic areas are at increased risk of a potentially fatal infection from Plasmodium falciparum, which requires prompt and aggressive treatment.
Described is a case of a 7-year-old boy who was infected by P. falciparum while in Africa and developed features of severe infection, including hyperparasitemia, altered neurologic status, and malarial hepatitis.
A single automated erythrocytapheresis procedure reduced parasitemia from 14% to less than 1%. Along with intravenous quinidine, this reduced parasite level was maintained throughout the hospitalization and the patient recovered.
Exchange transfusion (ET) is an effective adjunct therapy to reduce the parasite load in cases of severe P. falciparum malaria. When performed in certain defined settings, the benefits can outweigh the risks of the procedure. Discussed are the medical and technical considerations on the use of adjunctive ET for severe P. falciparum infection and a review of the literature of the use of adjunct ET in the treatment of severe P. falciparum malaria.
从疟疾流行地区返回美国的旅行者感染恶性疟原虫的风险增加，这可能导致致命的感染，需要及时和积极的治疗。
描述了一名 7 岁男孩在非洲感染恶性疟原虫的病例，该患者出现严重感染的特征，包括高疟原虫血症、神经状态改变和疟原虫性肝炎。
单次自动化红细胞分离术使疟原虫从 14%减少到不到 1%。与静脉注射奎宁一起，在整个住院期间维持了较低的寄生虫水平，患者得以康复。
换血疗法（ET）是一种有效的辅助治疗方法，可降低严重恶性疟原虫疟疾的寄生虫负荷。在某些特定情况下，该疗法的益处超过其风险。本文讨论了辅助 ET 在严重恶性疟原虫感染中的应用的医学和技术考虑因素，并回顾了辅助 ET 在治疗严重恶性疟原虫疟疾中的应用的文献。
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