部分换血疗法治疗重症恶性疟
Partial exchange transfusion in the treatment of severe falciparum malaria.
作者信息
Aquinas S, Ross C, Vincent J, Sridhar C B
机构信息
Department of Medicine, St. John's Medical College Hospital, Bangalore.
出版信息
Natl Med J India. 1996 Jul-Aug;9(4):163-5.
BACKGROUND
Exchange transfusion as an adjunct to the treatment of severe falciparum malaria has been widely recommended, although there is no well-designed clinical trial to prove its efficacy. The amount of compatible blood required for total exchange is rarely available in areas endemic for malaria and the risks of the procedure including transfusion-related infections are high.
METHODS
Partial transfusion with four units of blood was given to a patient with severe falciparum malaria (80% parasitaemia) whose condition deteriorated on conventional treatment with intravenous quinine.
RESULTS
This brought about prompt clinical improvement and reduction in parasitaemia.
CONCLUSION
Partial transfusion with one or two litres of blood is a promising and viable alternative to total exchange transfusion.
背景
尽管缺乏精心设计的临床试验来证明其疗效，但换血疗法作为重症恶性疟治疗的辅助手段已被广泛推荐。在疟疾流行地区，很少能获得全量换血所需的匹配血液，且该操作的风险（包括输血相关感染）很高。
方法
对一名重症恶性疟患者（疟原虫血症达80%）进行了四单位血液的部分输血，该患者在接受静脉注射奎宁的常规治疗后病情恶化。
结果
这带来了迅速的临床改善和疟原虫血症的降低。
结论
一或两升血液的部分输血是全量换血疗法的一种有前景且可行的替代方法。
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