Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.
Acta Neurol Scand. 2010 Mar;121(3):194-7. doi: 10.1111/j.1600-0404.2009.01159.x. Epub 2009 Dec 10.
Subjective feelings of memory decline are fairly common among the elderly. The causes of this are heterogeneous, and may be related to both affective and cognitive disorders. We attempted to explore the associations between subjective and cognitive measures.
Healthy subjects were studied. They completed questionnaires regarding memory difficulties and lifestyle habits, the Geriatric Depression scale (GDS), and the Spielberger State-Trait Anxiety Inventory. Cognitive functions were tested using the Mini-Mental State Exam and supplemented with NeuroTrax, a computerized neurophysiological battery. Univariate logistic regression model was applied to estimate odd ratios (OR) and 95% confidence intervals of associations.
Of 341 consecutive non-depressed subjects, 257 participants (75.4%) reported subjective memory decline (SMD). Subjects with and without SMD did not differ in age, gender, education, marital status, employment and life-style. Subjects with SMD had elevated GDS scores (OR = 1.14, 95% CI: 1.003-1.29), white anxiety level showed a tendency to be increased (OR = 1.03, 95% CI: 0.99-1.06). Comparison of cognitive performance has not revealed differences in cognitive domains between subjects with and without SMD.
SMD in healthy elderly people is associated with sub-clinical depression even among those without objectively measured cognitive decline.
老年人普遍存在主观记忆减退的感觉。其原因多种多样，可能与情感和认知障碍有关。我们试图探讨主观和认知测量之间的关系。
研究了健康受试者。他们完成了关于记忆困难和生活方式习惯、老年抑郁量表（GDS）和Spielberger 状态-特质焦虑量表的问卷。使用 Mini-Mental State 检查和 NeuroTrax（一种计算机化神经生理电池）测试认知功能。应用单变量逻辑回归模型估计关联的优势比（OR）和 95%置信区间。
在 341 名连续非抑郁受试者中，257 名受试者（75.4%）报告有主观记忆减退（SMD）。有和没有 SMD 的受试者在年龄、性别、教育、婚姻状况、就业和生活方式方面没有差异。有 SMD 的受试者 GDS 评分升高（OR=1.14，95%CI：1.003-1.29），焦虑水平呈升高趋势（OR=1.03，95%CI：0.99-1.06）。认知表现的比较并未显示有和无 SMD 的受试者在认知领域存在差异。
即使在没有客观测量认知下降的情况下，健康老年人的 SMD 也与亚临床抑郁有关。
