Fundação Universidade Federal de Rondônia. Porto Velho, RO, Brasil.
Acta Paediatr. 2010 Jun;99(6):934-9. doi: 10.1111/j.1651-2227.2009.01641.x. Epub 2009 Dec 9.
We studied the effect on neurodevelopment of infants who are exposed to thimerosal in tetanus-diphtheria (Td) vaccines during pregnancy.
We compared Gesell Developmental Schedules (GDS) of exclusive breastfed infants at 6 months born to mothers who received Td (1 to 3 doses) against those who were born to mothers who did not take such vaccines.
Compared with the group of infants not exposed to ethylmercury in utero, the infants of exposed mothers showed no significant difference in neurodevelopment delays. Although there was a significant correlation between hair-Hg of mothers and hair-Hg of neonates (Spearman r = 0.353; p = 0.0011), there was no significant correlation between the level of in utero exposure to ethylmercury in Td vaccines and neonate's hair-Hg concentrations (Spearman r = 0.060; p = 0.5922). However, regression analysis showed that GDS at 6 months was significantly associated with total mercury concentration of neonate's hair but was not sensitive to the number of vaccines taken by the mother.
Early neurodevelopment of exclusively breastfed infants is sensitive to in utero exposure to mercury, but maternal thimerosal exposure in tetanus-diphtheria vaccines per se cannot portend clinical neurodevelopment delays measured by GDS at 6 months.
我们研究了孕妇在破伤风白喉（Td）疫苗中接触硫柳汞对婴儿神经发育的影响。
我们比较了母亲接受 Td（1-3 剂）与未接受此类疫苗的母亲所生的纯母乳喂养婴儿在 6 个月时 Gesell 发育时间表（GDS）的差异。
与未在子宫内接触乙基汞的婴儿组相比，暴露于母亲的婴儿在神经发育迟缓方面没有显著差异。虽然母亲头发中的汞含量与新生儿头发中的汞含量之间存在显著相关性（Spearman r = 0.353；p = 0.0011），但 Td 疫苗中母体宫内乙基汞暴露水平与新生儿头发中汞浓度之间无显著相关性（Spearman r = 0.060；p = 0.5922）。然而，回归分析表明，6 个月时 GDS 与新生儿头发中总汞浓度显著相关，但对母亲接种疫苗的数量不敏感。
纯母乳喂养婴儿的早期神经发育对汞的宫内暴露敏感，但破伤风白喉疫苗中的母体硫柳汞暴露本身并不能预示 6 个月时 GDS 测量的临床神经发育迟缓。
