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帕金森病中的喘鸣:一例“干性溺水”?

Stridor in Parkinson's disease: a case of 'dry drowning'?

作者信息

Gan Eng Cern, Lau D P, Cheah K L

机构信息

Department of Otolaryngology, Singapore General Hospital, Singapore.

出版信息

J Laryngol Otol. 2010 Jun;124(6):668-73. doi: 10.1017/S0022215109992222. Epub 2009 Dec 11.

Abstract

OBJECTIVES

(1) To present a rare case of stridor secondary to prolonged laryngospasm in a patient with Parkinson's disease, and (2) to review the literature on stridor in Parkinson's disease.

METHODS

We report a 73-year-old Parkinson's disease patient who developed acute stridor due to prolonged laryngospasm triggered by overspill of excessive secretions. The literature was reviewed, following a Medline search using the keywords 'Parkinson's disease' and 'stridor' or 'airway obstruction' or 'laryngospasm' or 'laryngeal dystonia' or 'bilateral vocal cord palsy'.

RESULT

Only 12 previously reported cases of stridor in Parkinson's disease patients were identified. Causes included bilateral vocal fold palsy (eight cases), laryngospasm (five), and dystonia of the jaw and neck muscles (two). The mechanism of laryngospasm in our patient was similar to 'dry drowning', and has not previously been described.

CONCLUSION

Laryngospasm can be triggered in Parkinson's disease by excessive secretions entering the larynx. The mechanism is similar to 'dry drowning'. Treatment focuses on reducing secretions. The use of botulinum toxin to reduce spasm is inappropriate in this situation. This case emphasises the importance of recognising different causes of stridor in Parkinson's disease patients, as this affects management.

摘要

目的

(1)介绍一例帕金森病患者因长期喉痉挛继发喘鸣的罕见病例,(2)回顾帕金森病患者喘鸣的相关文献。

方法

我们报告了一名73岁的帕金森病患者,因过多分泌物溢出引发长期喉痉挛而出现急性喘鸣。在使用关键词“帕金森病”和“喘鸣”或“气道梗阻”或“喉痉挛”或“喉肌张力障碍”或“双侧声带麻痹”进行Medline检索后,对文献进行了回顾。

结果

仅发现12例先前报道的帕金森病患者喘鸣病例。病因包括双侧声带麻痹(8例)、喉痉挛(5例)以及颌部和颈部肌肉肌张力障碍(2例)。我们患者喉痉挛的机制类似于“干性溺水”,此前尚未有过描述。

结论

帕金森病患者可因过多分泌物进入喉部引发喉痉挛。其机制类似于“干性溺水”。治疗重点在于减少分泌物。在此情况下使用肉毒杆菌毒素减轻痉挛并不合适。该病例强调了识别帕金森病患者喘鸣不同病因的重要性,因为这会影响治疗管理。

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