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第四讲:心血管疾病、糖尿病和癌症:地中海饮食对 CHD 患者的应用证据。

Session 4: CVD, diabetes and cancer: Evidence for the use of the Mediterranean diet in patients with CHD.

机构信息

Centre for Public Health, Institute of Clinical Science B, Queen's University Belfast, Grosvenor Road, Belfast BT12 6BJ, UK.

出版信息

Proc Nutr Soc. 2010 Feb;69(1):45-60. doi: 10.1017/S0029665109991856. Epub 2009 Dec 15.

Abstract

Diet is associated with the development of CHD. The incidence of CHD is lower in southern European countries than in northern European countries and it has been proposed that this difference may be a result of diet. The traditional Mediterranean diet emphasises a high intake of fruits, vegetables, bread, other forms of cereals, potatoes, beans, nuts and seeds. It includes olive oil as a major fat source and dairy products, fish and poultry are consumed in low to moderate amounts. Many observational studies have shown that the Mediterranean diet is associated with reduced risk of CHD, and this result has been confirmed by meta-analysis, while a single randomised controlled trial, the Lyon Diet Heart study, has shown a reduction in CHD risk in subjects following the Mediterranean diet in the secondary prevention setting. However, it is uncertain whether the benefits of the Mediterranean diet are transferable to other non-Mediterranean populations and whether the effects of the Mediterranean diet will still be feasible in light of the changes in pharmacological therapy seen in patients with CHD since the Lyon Diet Heart study was conducted. Further randomised controlled trials are required and if the risk-reducing effect is confirmed then the best methods to effectively deliver this public health message worldwide need to be considered.

摘要

饮食与 CHD 的发生有关。与北欧国家相比,南欧国家 CHD 的发病率较低,有人提出这种差异可能是饮食的结果。传统的地中海饮食强调大量摄入水果、蔬菜、面包、其他谷物、土豆、豆类、坚果和种子。它以橄榄油作为主要脂肪来源,乳制品、鱼类和家禽的摄入量适中。许多观察性研究表明,地中海饮食可降低 CHD 的风险,荟萃分析也证实了这一结果,而一项单中心随机对照试验——里昂心脏研究表明,在二级预防中遵循地中海饮食可降低 CHD 风险。然而,地中海饮食的益处是否可以转移到其他非地中海人群,以及鉴于自里昂心脏研究以来 CHD 患者的药物治疗发生了变化,地中海饮食是否仍然可行,这些问题尚不确定。需要进一步的随机对照试验,如果能够证实这种降低风险的效果,那么就需要考虑在全球范围内有效传递这一公共卫生信息的最佳方法。

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