Area Académica de Sociedad, Cultura y Salud, El Colegio de la Frontera Sur, San Cristóbal de Las Casas, Chiapas, México.
Int J Tuberc Lung Dis. 2010 Jan;14(1):34-9.
To analyse the proportion of multidrug-resistant tuberculosis (MDR-TB) in cultures performed during the period 2000-2002 in Los Altos, Selva and Norte regions, Chiapas, Mexico, and to analyse MDR-TB in terms of clinical and sociodemographic indicators.
Cross-sectional study of patients with pulmonary tuberculosis (PTB) from the above regions. Drug susceptibility testing results from two research projects were analysed, as were those of routine sputum samples sent in by health personnel for processing (n = 114). MDR-TB was analysed in terms of the various variables of interest using bivariate tests of association and logistic regression.
The proportion of primary MDR-TB was 4.6% (2 of 43), that of secondary MDR-TB was 29.2% (7/24), while among those whose history of treatment was unknown the proportion was 14.3% (3/21). According to the logistic regression model, the variables most highly associated with MDR-TB were as follows: having received anti-tuberculosis treatment previously, cough of >3 years' duration and not being indigenous.
The high proportion of MDR cases found in the regions studied shows that it is necessary to significantly improve the control and surveillance of PTB.
分析 2000-2002 年期间在墨西哥恰帕斯州洛斯阿尔托斯、塞尔瓦和诺特地区进行的培养物中耐多药结核病（MDR-TB）的比例，并分析临床和社会人口学指标方面的 MDR-TB。
对来自上述地区的肺结核（PTB）患者进行横断面研究。分析了两个研究项目的药敏试验结果，以及卫生人员为处理而送检的常规痰样本（n=114）的结果。使用关联的双变量检验和逻辑回归分析，对 MDR-TB 与各种感兴趣变量进行分析。
原发性 MDR-TB 的比例为 4.6%（43 例中的 2 例），继发性 MDR-TB 的比例为 29.2%（24 例中的 7 例），而对于治疗史未知的患者，其比例为 14.3%（21 例中的 3 例）。根据逻辑回归模型，与 MDR-TB 最相关的变量如下：之前接受过抗结核治疗、咳嗽时间>3 年以及非原住民。
在所研究的地区发现的大量 MDR 病例表明，有必要显著加强对 PTB 的控制和监测。
