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来自墨西哥恰帕斯州美洲印第安人群体的分离株的遗传多样性。

Genetic Diversity of Isolates From an Amerindian Population in Chiapas, México.

机构信息

Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.

出版信息

Front Cell Infect Microbiol. 2022 Jul 13;12:875909. doi: 10.3389/fcimb.2022.875909. eCollection 2022.

DOI:10.3389/fcimb.2022.875909
PMID:35909960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9326120/
Abstract

This is the first report of the genetic diversity of the complex isolates found in a Mexican-Amerindian setting. In this study, we analyzed isolates collected from the Highlands region of Chiapas, Mexico, by using spoligotyping and whole-genome sequencing analyses. Seventy-three isolates were analyzed initially by spoligotyping; no new spoligotypes were identified. Nineteen percent of the isolates were identified as SIT53 (T1) (n = 14), followed by SIT42 (14%, n = 10, LAM9) and SIT119 (11%; n = 8, X1). SIT53, SIT42, and orphan isolates (16.4%, n = 12) constituted about 50% of the isolates studied and were subjected to whole-genome sequencing (WGS) analysis. Most SIT53 (10/12) isolates belonged to the Euro-American sub-lineage 4.8. Most SIT42 isolates (4/7) as .well as most orphan isolates (5/8) belonged to the lineage 4.3.3 LAM group. By comparing the single-nucleotide polymorphism (SNP) patterns of the SIT53 isolates, we found one clone (<7 SNPs) and four clustered isolates (<15 SNPs). In isolates from the SIT42 and orphan groups, we did not find any clones or clusters. This work demonstrates the success of sub-lineage 4.8 to predominate in Mexico and confirms the dominion of sub-lineage 4.3.3 in Central and South America.

摘要

这是首次报道在墨西哥裔美国人聚居区发现的 复合分离株的遗传多样性。在本研究中，我们通过 spoligotyping 和全基因组测序分析，对来自墨西哥恰帕斯高地地区的分离株进行了分析。最初通过 spoligotyping 分析了 73 个 分离株；未发现新的 spoligotype。19%的分离株被鉴定为 SIT53 (T1) (n = 14)，其次是 SIT42 (14%，n = 10，LAM9) 和 SIT119 (11%，n = 8，X1)。SIT53、SIT42 和孤立分离株 (16.4%，n = 12) 约占研究分离株的 50%，并进行了全基因组测序 (WGS) 分析。大多数 SIT53 (10/12) 分离株属于欧亚美亚谱系 4.8。大多数 SIT42 分离株 (4/7) 以及大多数孤立分离株 (5/8) 属于谱系 4.3.3 LAM 组。通过比较 SIT53 分离株的单核苷酸多态性 (SNP) 模式，我们发现了一个克隆 (<7 SNPs) 和四个聚类分离株 (<15 SNPs)。在 SIT42 和孤立组的分离株中，我们没有发现任何克隆或聚类。这项工作表明，亚谱系 4.8 成功在墨西哥占主导地位，并证实了亚谱系 4.3.3 在中美洲和南美洲的统治地位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/df27d93bd137/fcimb-12-875909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/8511ef85b075/fcimb-12-875909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/1f19e26738ff/fcimb-12-875909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/8b21ac7e3bc7/fcimb-12-875909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/f8cd5a1ebdd7/fcimb-12-875909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/ccfcf31689e8/fcimb-12-875909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/df27d93bd137/fcimb-12-875909-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/8511ef85b075/fcimb-12-875909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/1f19e26738ff/fcimb-12-875909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/8b21ac7e3bc7/fcimb-12-875909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/f8cd5a1ebdd7/fcimb-12-875909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/ccfcf31689e8/fcimb-12-875909-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb7c/9326120/df27d93bd137/fcimb-12-875909-g006.jpg

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