Oliveira C M, Dantas A L A, Dantas B M
Instituto de Radioproteção e Dosimetria, Comissão Nacional de Energia Nuclear Av. Salvador Allende - CEP 22780-160, Rio de Janeiro, RJ, Brasil.
Cell Mol Biol (Noisy-le-grand). 2009 Nov 15;55(3):29-33.
The objective of this work is to develop procedures for internal monitoring of (18)F to be applied in cases of possible incorporation of fluoride and (18)FDG, using in vivo and in vitro methods of measurements. The Na I (Tl) 8" x 4" scintillation detector installed at IRD-Whole Body Counter was calibrated for measurements with a whole body anthropomorphic phantom, simulating homogeneous distribution of (18)F in the body. The NaI(Tl) 3"x 3" scintillation detector installed at the IRD-Whole Body Counter was calibrated for in vivo measurements with a brain phantom inserted in an artificial skull, simulating (18)FDG incorporation. The HPGe detection system installed at the IRD-Bioassay Laboratory was calibrated for in vitro measurements of urine samples with 1 liter plastic bottles containing a standard liquid source. A methodology for bioassay data interpretation, based on standard ICRP models edited with the software AIDE-version 6, was established. It is concluded that in vivo measurements have sufficient sensitivity for monitoring (18)F in the forms of fluoride and (18)FDG. The use of both in vitro and in vivo bioassay data can provide useful information for the interpretation of bioassay data in cases of accidental incorporation in order to identify the chemical form of (18)F incorporated.
本工作的目的是开发用于体内监测¹⁸F的程序，以便在可能摄入氟化物和¹⁸F-FDG的情况下应用，采用体内和体外测量方法。安装在IRD全身计数器上的Na I（Tl）8英寸×4英寸闪烁探测器，使用全身人体模型进行校准，以模拟¹⁸F在体内的均匀分布。安装在IRD全身计数器上的NaI（Tl）3英寸×3英寸闪烁探测器，使用插入人工颅骨的脑部模型进行校准，以模拟¹⁸F-FDG的摄入情况，用于体内测量。安装在IRD生物测定实验室的HPGe检测系统，使用装有标准液体源的1升塑料瓶对尿液样本进行体外测量校准。基于用软件AIDE-版本6编辑的ICRP标准模型，建立了生物测定数据解释方法。得出的结论是，体内测量对监测氟化物形式和¹⁸F-FDG形式的¹⁸F具有足够的灵敏度。在意外摄入的情况下，结合使用体外和体内生物测定数据可为生物测定数据的解释提供有用信息，以便确定摄入的¹⁸F的化学形式。
