Zavorsky G S, Kryder J R, Jacob S V, Coates A L, Davis G M, Lands L C
Department of Obstetrics, Gynecology, and Women's Health, Saint Louis University, Saint Louis, MO 63117, USA.
Clin Invest Med. 2009 Dec 1;32(6):E302. doi: 10.25011/cim.v32i6.10666.
Pulmonary function of children with cystic fibrosis (CF) and bronchopulmonary dysplasia (BPD) is similar at rest even though the mechanisms of injury differ. We sought to compare the peak exercise responses in children with BPD versus CF while controlling for pulmonary impairment, nutritional status, gender, age, height, and predicted forced expired volume in 1 second (approximately 73% of predicted).
Nine BPD children and 9 CF children underwent spirometry and a progressive exercise test to maximum on a cycle ergometer.
There was no difference between groups in body mass percentile (CF:97 +/- 13%, BPD: 98 +/- 11%), peak power output (Wpeak) (CF:67 +/- 19 W, BPD:73 +/- 28 W), % predicted Wpeak (CF:83 +/- 28%, BPD:88 +/- 15%), peak oxygen uptake (VO2peak, CF: 38 +/- 7 ml/kg/min, BPD: 39 +/-6 ml/kg/min), or % predicted VO2peak (CF:99 +/- 16 %, BPD:96 +/- 27%).
Children with mild pulmonary impairments are able to achieve a near normal peak power output and a normal VO2peak. Neither the aetiology nor the developmental onset of the process appears to be important influences on VO2peak or Wpeak.
尽管囊性纤维化（CF）和支气管肺发育不良（BPD）患儿的损伤机制不同，但他们在静息状态下的肺功能相似。我们试图在控制肺功能损害、营养状况、性别、年龄、身高以及预计1秒用力呼气量（约为预计值的73%）的情况下，比较BPD患儿和CF患儿的运动峰值反应。
9名BPD患儿和9名CF患儿接受了肺活量测定，并在自行车测力计上进行了递增运动测试直至极限。
两组患儿的体重百分位数（CF：97±13%，BPD：98±11%）、峰值功率输出（Wpeak）（CF：67±19W，BPD：73±28W）、预计Wpeak的百分比（CF：83±28%，BPD：88±15%）、峰值摄氧量（VO2peak，CF：38±7ml/kg/min，BPD：39±6ml/kg/min）或预计VO2peak的百分比（CF：99±16%，BPD：96±27%）均无差异。
轻度肺功能损害的患儿能够达到接近正常的峰值功率输出和正常的VO2peak。病因和发病过程的发育起始似乎都不是影响VO2peak或Wpeak的重要因素。
