经破伤风-白喉联合疫苗（Td）肌内注射免疫后，血液中抗脊灰病毒（polio）和抗单纯疱疹病毒（HSV）IgA 前浆细胞反应被刺激。
Stimulation of anti-polio and anti-HSV IgA pre-plasma cell response in blood following parenteral immunization with tetanus-diphtheria vaccine.
机构信息
Department of Pathology and Molecular Medicine, McMaster University, Histocompatibility Lab, Hamilton Health Sciences, Hamilton, ON, Canada.
出版信息
Vaccine. 2010 Feb 10;28(6):1493-8. doi: 10.1016/j.vaccine.2009.11.057. Epub 2009 Dec 8.
Systemic immunization can elicit a significant response of IgG producing activated B cell subsets in human blood, part of which is not toward the vaccine. However, the effect of vaccination on IgA antibody secreting B cell subsets has had limited investigation. We immunized healthy, adult volunteers with a tetanus/diphtheria vaccine and observed a significant burst of IgA-secreting pre-plasma cells (PPC). Isolated PPC produced IgG, but not IgA antibody to tetanus antigen, and produced IgA and IgG antibody specific for poliovirus and herpes simplex virus. Thus, a vaccine that generates a systemic recall response to tetanus also induces blood PPC secreting IgA and IgG antibody relevant to mucosal protection.
全身免疫可以在人体血液中引发 IgG 产生的活化 B 细胞亚群的显著反应，其中一部分不是针对疫苗的。然而，疫苗接种对 IgA 抗体分泌 B 细胞亚群的影响的研究还很有限。我们用破伤风/白喉疫苗对健康的成年志愿者进行免疫接种，观察到 IgA 分泌前浆细胞（PPC）的显著爆发。分离的 PPC 产生 IgG，但不产生破伤风抗原的 IgA 抗体，并且产生针对脊髓灰质炎病毒和单纯疱疹病毒的 IgA 和 IgG 抗体。因此，一种能引起破伤风全身回忆反应的疫苗也能诱导血液 PPC 分泌与粘膜保护相关的 IgA 和 IgG 抗体。
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