Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 4th Floor, Philadelphia, PA 19104, USA.
Drug Alcohol Depend. 2010 Mar 1;107(2-3):237-43. doi: 10.1016/j.drugalcdep.2009.11.001. Epub 2009 Dec 9.
Nicotine replacement therapies are efficacious for treating nicotine dependence. However, limited data exist on benefits of different NRTs and predictors of treatment outcome. This study compared the effectiveness of transdermal nicotine vs. nicotine lozenge for smoking cessation and identified predictors of treatment response.
A randomized, open-label effectiveness trial was conducted at 12 medical sites participating in the National Cancer Institute's Community Clinical Oncology Program. The sample consisted of 642 treatment-seeking smokers randomized to 12 weeks of transdermal nicotine or nicotine lozenge.
Smoker characteristics were assessed at baseline, and 24-h point prevalence abstinence confirmed with breath carbon monoxide (CO) was evaluated at end of treatment (EOT) and at a 6-month follow-up. There was a trend for higher quit rates for transdermal nicotine vs. nicotine lozenge at EOT (24.3% vs. 18.7%, p=.10) and 6 months (15.6% vs. 10.9%, p=.10). A logistic regression model of EOT quit rates showed smokers who preferred transdermal nicotine, were not reactive to smoking cues, and did not use nicotine to alleviate distress or stimulate cognitive function had higher quit rates on transdermal nicotine. A logistic regression model of 6-month quit rates showed smokers who preferred transdermal nicotine had higher quit rates on transdermal nicotine, and smokers who used nicotine to alleviate distress or stimulate cognitive processes had lower quit rates on nicotine lozenge.
Transdermal nicotine may be more effective than nicotine lozenge for smokers who prefer transdermal nicotine and do not smoke to alleviate emotional distress or stimulate cognitive function.
尼古丁替代疗法对治疗尼古丁依赖是有效的。然而，关于不同尼古丁替代疗法的益处以及治疗结果预测因素的数据有限。本研究比较了皮肤贴片尼古丁与尼古丁口含片戒烟的效果，并确定了治疗反应的预测因素。
在参与美国国家癌症研究所社区临床肿瘤学计划的 12 个医疗站点进行了一项随机、开放标签的有效性试验。该样本包括 642 名寻求治疗的吸烟者，他们被随机分配到为期 12 周的皮肤贴片尼古丁或尼古丁口含片治疗组。
在基线时评估吸烟者的特征，并在治疗结束时（EOT）和 6 个月随访时使用呼气一氧化碳（CO）确认 24 小时点患病率的戒烟情况。皮肤贴片尼古丁组的戒烟率高于尼古丁口含片组，EOT 时的戒烟率为 24.3%比 18.7%（p=.10），6 个月时的戒烟率为 15.6%比 10.9%（p=.10）。EOT 戒烟率的逻辑回归模型显示，喜欢皮肤贴片尼古丁、对吸烟线索不敏感且不使用尼古丁缓解痛苦或刺激认知功能的吸烟者，皮肤贴片尼古丁的戒烟率更高。6 个月戒烟率的逻辑回归模型显示，喜欢皮肤贴片尼古丁的吸烟者在皮肤贴片尼古丁上的戒烟率更高，而使用尼古丁缓解痛苦或刺激认知过程的吸烟者在尼古丁口含片上的戒烟率更低。
对于喜欢皮肤贴片尼古丁且不吸烟缓解情绪困扰或刺激认知功能的吸烟者，皮肤贴片尼古丁可能比尼古丁口含片更有效。
