洞悉林可酰胺类抗生素耐药性的奥秘

Insights into resistance against lincosamide antibiotics.

机构信息

Department of Structural Biology, Hauptman-Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, NY, USA.

出版信息

Structure. 2009 Dec 9;17(12):1549-1550. doi: 10.1016/j.str.2009.11.001.

DOI:10.1016/j.str.2009.11.001

PMID:20004157

Abstract

Bacteria utilize multiple strategies to circumvent antibiotics, producing broad specificity exporters or enzymes that catalyze the modification of either antibiotics or their targets. A report in this issue of Structure provides the structural and catalytic mechanisms of LinB, an adenylyltransferase of E. faecium that confers resistance to the lincosamide antibiotic clindamycin.

摘要

细菌利用多种策略来规避抗生素，产生广谱特异性外排泵或酶，这些酶可以催化抗生素或其靶标的修饰。本期《结构》杂志的一篇报道提供了林 B 的结构和催化机制，林 B 是屎肠球菌中的一种腺嘌呤转移酶，使该菌对林可酰胺类抗生素克林霉素产生耐药性。