Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
Transl Res. 2010 Jan;155(1):20-6. doi: 10.1016/j.trsl.2009.08.009.
The clinical presentation of systemic vasculitis can vary widely and include skin disorders, neuropathy, eye symptoms, and systemic inflammation. The precise molecular mechanisms underlying this syndrome are not fully understood, but the importance of a chronic imbalance of the cytokines and chemokines involved in orchestrating inflammatory responses is now recognized. In similar fashion, atherosclerosis is now recognized to be a chronic inflammatory disease in which chemokines play important roles. In the current review, we discuss the involvement of CX3CL1, which is a unique member of the chemokine family, and its receptor, CX3CR1, in the pathogenesis of these vasculopathies.
系统性血管炎的临床表现差异很大，包括皮肤疾病、神经病、眼部症状和全身炎症。该综合征的确切分子机制尚不完全清楚，但现在已经认识到涉及调节炎症反应的细胞因子和趋化因子慢性失衡的重要性。同样，现在已经认识到动脉粥样硬化是一种慢性炎症性疾病，其中趋化因子发挥重要作用。在当前的综述中，我们讨论了趋化因子家族中独特的成员 CX3CL1 及其受体 CX3CR1 在这些血管病变发病机制中的作用。
