INSERM, U 782, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris-Sud, UMR-S0782, and Hôpital Antoine Béclère, Clamart, France.
Fertil Steril. 2010 Aug;94(3):1141-3. doi: 10.1016/j.fertnstert.2009.10.049. Epub 2009 Dec 11.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo implantation. We therefore confirmed the endometrial presence of TWEAK/fibroblast growth factor inducible-14 (Fn-14) and documented simultaneously the cytotoxic KIR receptor (NKp46) of uNK cells in the human endometrium while TWEAK, Fn-14, IL-15, and IL-18 mRNA were quantified by real-time polymerase chain reaction in relation to the recruitment of CD56+ cells among fertile control women and patients who had failed to implant after assisted reproduction treatment.
肿瘤坏死因子样凋亡弱诱导剂（TWEAK）可能在白细胞介素（IL）-15 和 IL-18 的调节中发挥作用，这些细胞因子对于胚胎植入过程中的血管生成和子宫自然杀伤（uNK）细胞募集至关重要。因此，我们在人子宫内膜中证实了 TWEAK/成纤维细胞生长因子诱导-14（Fn-14）的存在，并同时记录了 uNK 细胞的细胞毒性杀伤细胞免疫球蛋白样受体（NKp46），而 TWEAK、Fn-14、IL-15 和 IL-18mRNA 的定量则通过实时聚合酶链反应进行，与在有生育能力的对照组女性和辅助生殖治疗后未能着床的患者中 CD56+细胞的募集有关。
