肥胖症和2型糖尿病患者血清脂联素与瘦素水平的相关性
Correlation of Serum Adiponectin and Leptin levels in Obesity and Type 2 Diabetes Mellitus.
作者信息
Diwan Arundhati G, Kuvalekar Aniket A, Dharamsi Siddharth, Vora Aditya M, Nikam Vivek A, Ghadge Abhijit A
机构信息
Department of Medicine, Bharati Vidyapeeth Medical College and Hospital, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.
Diabetes Laboratory, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.
出版信息
Indian J Endocrinol Metab. 2018 Jan-Feb;22(1):93-99. doi: 10.4103/ijem.IJEM_491_15.
INTRODUCTION
Indian phenotype includes higher waist circumference despite lower body mass index, thereby making Indians more prone to diabetes and its complications.
AIM
The present study aimed to analyze the serum levels of adiponectin and leptin in the participants with type 2 diabetes mellitus (T2DM) and obesity and their correlation with hypertension and dyslipidemia.
MATERIALS AND METHODS
In the study, 50 diabetics and 50 controls aged between 40 and 60 years were included in the study.
RESULTS
Adiponectin levels were significantly higher in diabetics than in nondiabetic participants irrespective of gender ( ≤ 0.04 in males, ≤ 0.02 in females). Leptin levels were significantly higher in diabetics compared to nondiabetics ( ≤ 0.001) in both males and females.
CONCLUSION
Adiponectin and leptin levels may be used as important clinical markers for T2DM and obesity.
引言
尽管印度人的体重指数较低，但他们的腰围却更高，这使得印度人更容易患糖尿病及其并发症。
目的
本研究旨在分析2型糖尿病（T2DM）和肥胖参与者的血清脂联素和瘦素水平，以及它们与高血压和血脂异常的相关性。
材料与方法
本研究纳入了50名年龄在40至60岁之间的糖尿病患者和50名对照者。
结果
无论性别如何，糖尿病患者的脂联素水平均显著高于非糖尿病参与者（男性≤0.04，女性≤0.02）。男性和女性糖尿病患者的瘦素水平均显著高于非糖尿病患者（≤0.001）。
结论
脂联素和瘦素水平可作为T2DM和肥胖的重要临床标志物。
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