Department of Pediatrics, Division of Endocrinology, Diabetes & Metabolism, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
J Pediatr. 2010 Apr;156(4):592-7.e2. doi: 10.1016/j.jpeds.2009.10.014. Epub 2009 Dec 14.
To examine whether anthropometric measurements, blood pressure (BP), fasting total cholesterol, and low-density lipoprotein are related to ultrasound measures of carotid intima-media thickness (CIMT) in children and teenagers with no known risk factors for cardiovascular disease.
This cross-sectional study included 599 subjects, 6 to 20 years of age (292 males, 307 females; 224 Hispanics, 210 European-Americans, 126 African-Americans, and 39 Asian-Americans) whose body mass index, waist circumference, BP, lipid profiles, and values for CIMT were determined.
Measures of CIMT were significantly greater in males than females (P=.006) and in African-Americans when compared with other ethnic groups (all P < .05). There were no relations between age, diastolic BP, or fasting levels of triglycerides, total cholesterol, or low-density lipoprotein values and CIMT measures, regardless of sex or ethnic background. Stratified multiple regression analysis indicated that body mass index and waist circumference independently predicted CIMT in both males and females, even after controlling for age, weight, BP, fasting lipid levels, and ethnic background.
Increased body mass and adiposity are associated with increased intima-media thickness in children and teenagers. This association is present in children not considered overweight, underscoring the need for the continued promotion of adequate nutritional and physical exercise behavior during childhood.
探讨在无心血管疾病已知危险因素的儿童和青少年中，人体测量学指标、血压（BP）、空腹总胆固醇和低密度脂蛋白是否与颈动脉内膜中层厚度（CIMT）的超声测量值相关。
这是一项横断面研究，共纳入 599 名 6 至 20 岁的受试者（男 292 名，女 307 名；西班牙裔 224 名，欧洲裔美国人 210 名，非裔美国人 126 名，亚裔美国人 39 名），对其进行了体重指数、腰围、BP、血脂谱和 CIMT 值的检测。
男性的 CIMT 测量值明显大于女性（P=.006），非洲裔美国人的 CIMT 测量值明显大于其他种族群体（均 P<.05）。无论性别或种族背景如何，年龄、舒张压或空腹甘油三酯、总胆固醇或低密度脂蛋白水平与 CIMT 测量值之间均无相关性。分层多元回归分析表明，在男性和女性中，体重指数和腰围均独立预测 CIMT，即使在控制年龄、体重、BP、空腹血脂水平和种族背景后也是如此。
体重增加和肥胖与儿童和青少年的内膜中层厚度增加有关。这种相关性存在于不被认为超重的儿童中，这突显了在儿童时期持续促进适当营养和身体活动行为的必要性。
