癌症发展中的淋巴细胞：向促肿瘤免疫的极化。
Lymphocytes in cancer development: polarization towards pro-tumor immunity.
机构信息
Department of Pathology, University of California, San Francisco, CA 94143, United States.
出版信息
Cytokine Growth Factor Rev. 2010 Feb;21(1):3-10. doi: 10.1016/j.cytogfr.2009.11.002. Epub 2009 Dec 11.
Abstract
The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.
摘要
经典观点认为，免疫细胞在癌症中的作用主要是肿瘤排斥，而现在则认为白细胞具有促进和抑制肿瘤的双重特性，这一观点更为复杂。这种转变归因于几种髓样细胞类型的能力已被充分认识，这些细胞类型促进了癌前组织的促肿瘤编程，以及发现白细胞亚群也抑制了淋巴细胞的发育和效应功能，而淋巴细胞对于介导抗肿瘤免疫至关重要。在这篇综述中，我们重点关注 T 淋巴细胞在促进肿瘤发展中未被充分认识的作用。除了 T 调节细胞的作用外，自然杀伤 T 细胞和 CD4(+)T 辅助细胞在抑制抗肿瘤免疫和促进癌症生长和转移方面也发挥了作用。
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