心脏型 alpha-2 巨球蛋白及其作为 HIV 患者心脏标志物的可靠性。
Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients.
机构信息
Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.
出版信息
Heart Lung Circ. 2010 Feb;19(2):93-5. doi: 10.1016/j.hlc.2009.10.005. Epub 2009 Dec 11.
BACKGROUND
Cardiac isoform of alpha 2 macroglobulin (CA2M), a serum protein (182000Mr) has been used as a diagnostic molecular marker for cardiac manifestations in HIV and diabetic patients. This study investigates the reliability of CA2M as an early diagnostic marker for cardiac manifestations in HIV patients and factors that could possibly influence their levels.
METHODS
A total of 206 serum samples were analysed from HIV patients with cardiac diseases (68), with non-cardiac ailments (48), opportunistic infections (34) and without other co-morbidities (56). The immuno-cross-reactivity between human serum CA2M and anti-rat CA2M antibody was tested and quantified by sandwich enzyme linked immunosorbent assay (ELISA).
RESULTS
The CA2M levels were high in HIV patients with cardiac diseases irrespective of the manifestations. The CA2M levels were not influenced by opportunistic infections, non-cardiac ailments and patient parameters like age, sex, duration of illness, past history of other co-morbidities.
CONCLUSION
CA2M can be used as a reliable early diagnostic marker in HIV patients with cardiac manifestations. CA2M levels were not influenced by other patient parameters.
背景
心脏型α2 巨球蛋白（CA2M）是一种血清蛋白（分子量为 182000），已被用作 HIV 和糖尿病患者心脏表现的诊断分子标志物。本研究旨在探讨 CA2M 作为 HIV 患者心脏表现早期诊断标志物的可靠性，以及可能影响其水平的因素。
方法
分析了 206 例患有心脏疾病（68 例）、非心脏疾病（48 例）、机会性感染（34 例）和无其他合并症（56 例）的 HIV 患者的血清样本。采用夹心酶联免疫吸附试验（ELISA）检测并定量人血清 CA2M 与抗大鼠 CA2M 抗体之间的免疫交叉反应性。
结果
无论临床表现如何，患有心脏疾病的 HIV 患者的 CA2M 水平均较高。CA2M 水平不受机会性感染、非心脏疾病以及患者的年龄、性别、病程、其他合并症的既往史等参数的影响。
结论
CA2M 可作为 HIV 患者心脏表现的可靠早期诊断标志物。CA2M 水平不受其他患者参数的影响。
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