Rathinavel Andiappan, Dhandapany Perundurai S, Annapoorani Ponnambalam, Ramasamy Subbiah, Selvam Govindan Sadasivam
Department of Cardio-Thoracic Surgery, Madurai Medical College and Government Rajaji Hospital, Madurai, Tamil Nadu, India.
Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):601-3. doi: 10.1097/01.hjr.0000176513.07037.83.
Earlier we showed cardiac isoform of alpha-2 macroglobulin (CA2M) to be an early marker of cardiac hypertrophy.
In this study, we tried to explore the possibility of using this protein as a marker for diagnosis of cardiac diseases.
A total of 593 samples were analyzed for the presence of CA2M using sandwich enzyme-linked immunosorbent assay.
Samples include various cardiac diseases (230), non-cardiac ailments (263) and controls (100).
Levels of CA2M in cardiac diseases were significantly higher than other sample groups but moderately elevated in leprosy. This protein could be considered for diagnosis of cardiac diseases as a serum marker.
此前我们发现α-2巨球蛋白的心脏异构体（CA2M）是心脏肥大的早期标志物。
在本研究中，我们试图探索将这种蛋白质用作心脏病诊断标志物的可能性。
使用夹心酶联免疫吸附测定法对总共593份样本进行CA2M检测。
样本包括各种心脏病患者（230例）、非心脏疾病患者（263例）和对照组（100例）。
心脏病患者体内CA2M水平显著高于其他样本组，但在麻风病患者体内中度升高。这种蛋白质可作为血清标志物用于心脏病的诊断。
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