The Salk Institute for Biological Studies, La Jolla, CA, USA.
Neuropsychologia. 2010 Mar;48(4):1047-52. doi: 10.1016/j.neuropsychologia.2009.12.002. Epub 2009 Dec 11.
Williams syndrome is a neurological condition associated with high levels of auditory reactivity and emotional expression combined with impaired perception of prosody. Yet, little is currently known about the neural organization of affective auditory processing in individuals with this disorder. The current study examines auditory emotion processing in individuals with Williams syndrome. Hemispheric organization for positive and negative human non-linguistic sound processing was compared in participants with and without the disorder using a dichotic listening paradigm. While controls exhibited an expected right cerebral hemisphere advantage for processing negative sounds, those with Williams syndrome showed the opposite pattern. No differences between the groups emerged for the positive stimuli. The results suggest aberrant processing of negative auditory information in Williams syndrome.
威廉斯综合征是一种与高水平听觉反应和情感表达相关的神经疾病，同时伴有韵律知觉障碍。然而，目前对于该障碍个体的情感听觉处理的神经组织知之甚少。本研究探讨了威廉斯综合征个体的听觉情绪处理。使用双耳分听范式比较了有和无该障碍个体对正性和负性人类非语言声音处理的半球组织。虽然对照组在处理负性声音时表现出预期的右半球优势，但患有威廉斯综合征的个体则表现出相反的模式。对于正性刺激，两组之间没有差异。结果表明，威廉斯综合征个体对负性听觉信息的处理异常。
