Ng Rowena, Lai Philip, Brown Timothy T, Järvinen Anna, Halgren Eric, Bellugi Ursula, Trauner Doris
a Laboratory for Cognitive Neuroscience , Salk Institute for Biological Studies , La Jolla , CA , USA.
b Institute of Child Development , University of Minnesota , Minneapolis , MN , USA.
Soc Neurosci. 2018 Dec;13(6):688-700. doi: 10.1080/17470919.2017.1386126. Epub 2017 Oct 9.
In this study, MRI and DTI were employed to examine subcortical volume and microstructural properties (FA, MD) of the limbic network, and their relationships with affect discrimination in 13 FL (6 right FL, M = 10.17 years; 7 left FL; M = 10.09) and 13 typically-developing children (TD; M = 10.16). Subcortical volume of the amygdala, hippocampus and thalamus and FA and MD of the fornix and anterior thalamic radiation (ATR) were examined. Results revealed no group differences across emotion-perception tasks or amygdalar volume. However, contrasting neuroanatomical patterns were observed in right versus left FL youth. Right FL participants showed increased left hippocampal and thalamic volume relative to left FL participants; whereas, the latter group showed increased right thalamic volume. DTI findings also indicated right FL children show greater MD of right fornix than other groups, whereas, left FL youth showed greater MD of left fornix. Right FL youth also showed lower FA of right fornix than left FL children, whereby the latter showed greater FA of left fornix and ATR. Differential associations between DTI indices and auditory/visual emotion-perception were observed across FL groups. Findings indicate diverging brain-behavioral relationships for emotion-perception among right and left FL children.
在本研究中，采用磁共振成像（MRI）和扩散张量成像（DTI）来检查边缘系统网络的皮质下体积和微观结构特性（各向异性分数[FA]、平均扩散率[MD]），以及它们与13名左利手儿童（6名右利手左利手儿童，平均年龄M = 10.17岁；7名左利手儿童，平均年龄M = 10.09岁）和13名发育正常儿童（TD；平均年龄M = 10.16岁）情感辨别能力之间的关系。检查了杏仁核、海马体和丘脑的皮质下体积以及穹窿和丘脑前辐射（ATR）的FA和MD。结果显示，在情绪感知任务或杏仁核体积方面，两组之间没有差异。然而，在右利手左利手儿童与左利手儿童中观察到了相反的神经解剖学模式。与左利手儿童相比，右利手左利手儿童的左侧海马体和丘脑体积增大；而后者右侧丘脑体积增大。DTI结果还表明，右利手左利手儿童右侧穹窿的MD大于其他组，而左利手儿童左侧穹窿的MD更大。右利手左利手儿童右侧穹窿的FA也低于左利手儿童，而后者左侧穹窿和ATR的FA更大。在不同的左利手儿童组中，观察到DTI指标与听觉/视觉情绪感知之间存在不同的关联。研究结果表明，右利手和左利手儿童在情绪感知方面存在不同的脑-行为关系。
