Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC.
Metabolism. 2010 Jun;59(6):802-7. doi: 10.1016/j.metabol.2009.09.027. Epub 2009 Dec 16.
A positive association between serum uric acid and metabolic syndrome has been reported, but little information is available about the association between serum uric acid and metabolic syndrome in Taiwanese adults. The purpose of this study was to investigate the association between serum uric acid levels and metabolic syndrome in Taiwanese adults. We performed a cross-sectional study of 2085 men and 1557 women. All of the participants underwent a health screening during the period from January 2005 to December 2005 at a health center of the Shin Kong Wu Ho-Su Memorial Hospital. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The results showed that hyperuricemia was significantly associated with increased risk for hypertriglyceridemia, low high-density lipoprotein cholesterol level, and high blood pressure in men and women. The risk of metabolic syndrome was significantly higher in the fourth quartile than in the first quartile of uric acid level in men (odds ratio [OR], 1.50; 95% confidence interval [CI], 1.06-2.14) and women (OR, 2.33; 95% CI, 1.39-3.93). In addition, uric acid level was inversely associated with hyperglycemia in men. The ORs of hyperglycemia for the second, third, and fourth quartile of uric acid were 0.69 (95% CI, 0.46-1.03), 0.55 (95% CI, 0.37-0.83), and 0.45 (95% CI, 0.29-0.69), respectively, compared with the lowest quartile of uric acid. The results demonstrate that there is a positive association between serum uric acid levels and metabolic syndrome and an inverse association between uric acid and fasting plasma glucose in Taiwanese adults.
已有研究表明，血清尿酸与代谢综合征之间呈正相关，但有关台湾成年人血清尿酸与代谢综合征之间关系的信息较少。本研究旨在探讨台湾成年人血清尿酸水平与代谢综合征之间的关系。我们对 2085 名男性和 1557 名女性进行了横断面研究。所有参与者均于 2005 年 1 月至 12 月期间在台北长庚纪念医院新光吴火狮纪念医院的一个健康中心接受了健康筛查。代谢综合征的定义根据国家胆固醇教育计划成人治疗专家组 III 标准。结果表明，高尿酸血症与男性和女性的高三酰甘油血症、低高密度脂蛋白胆固醇水平和高血压风险显著相关。与尿酸水平最低四分位相比，男性尿酸四分位第 4 位发生代谢综合征的风险显著更高（比值比 [OR]，1.50；95%置信区间 [CI]，1.06-2.14）和女性（OR，2.33；95%CI，1.39-3.93）。此外，尿酸水平与男性的高血糖呈负相关。尿酸四分位第 2、3、4 位的高血糖比值比（OR）分别为 0.69（95%CI，0.46-1.03）、0.55（95%CI，0.37-0.83）和 0.45（95%CI，0.29-0.69），与尿酸最低四分位相比。结果表明，在台湾成年人中，血清尿酸水平与代谢综合征呈正相关，而尿酸与空腹血糖呈负相关。
