Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Gastroenterology and Hepathology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinol Diabetes Metab. 2022 Jan;5(1):e00311. doi: 10.1002/edm2.311. Epub 2021 Oct 27.
This study aimed to determine a parameter to more easily diagnose metabolic syndrome and predict its probability of occurrence in high-risk individuals.
In this cross-sectional study, data related to the study population in the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS) were examined. Subjects were divided into two groups with and without metabolic syndrome, and the relevant factors such as the ratios of uric acid to high-density lipoprotein (HDL) (UHR) in these two groups were compared, and the best cut-off point was determined.
Data related to 817 people including 96 people with metabolic syndrome and 721 people without metabolic syndrome were analysed. The mean UHR was significantly higher in patients with metabolic syndrome (14.76 ± 6.33%) compared with those without metabolic syndrome (10.0 ± 3.10%) (p < .001). People with high UHR are 2.9 times more at risk of metabolic syndrome and the best cut-off point was 9.50% with 86% sensitivity and 55% specificity.
According to our study, UHR is also helpful in diagnosing metabolic syndrome and can also be used to screen people at risk for metabolic syndrome.
本研究旨在确定一个参数，以便更轻松地诊断代谢综合征，并预测其在高危人群中的发生概率。
在这项横断面研究中，对克尔曼冠状动脉疾病风险因素研究（KERCADRS）研究人群的数据进行了检查。将受试者分为有代谢综合征和无代谢综合征两组，比较两组尿酸与高密度脂蛋白（HDL）比值（UHR）等相关因素，并确定最佳截断值。
分析了 817 人，包括 96 名代谢综合征患者和 721 名无代谢综合征患者。与无代谢综合征患者（10.0±3.10%）相比，代谢综合征患者的 UHR 平均值明显更高（14.76±6.33%）（p<0.001）。UHR 较高的人群患代谢综合征的风险增加 2.9 倍，最佳截断值为 9.50%，敏感性为 86%，特异性为 55%。
根据我们的研究，UHR 也有助于诊断代谢综合征，还可以用于筛查代谢综合征高危人群。
