伏立康唑在豚鼠侵袭性毛孢子菌病模型中的疗效。
Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis.
作者信息
Serena Carolina, Gilgado Félix, Mariné Marçal, Pastor F Javier, Guarro Josep
机构信息
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, Reus, Spain.
出版信息
Antimicrob Agents Chemother. 2006 Jun;50(6):2240-3. doi: 10.1128/AAC.00045-06.
Abstract
We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.
摘要
我们评估了伏立康唑（VRC）在免疫抑制豚鼠中对阿萨希毛孢子菌全身感染的疗效。在延长生存期和减轻组织负荷方面，伏立康唑比两性霉素B更有效。以10mg/kg体重/天的伏立康唑治疗效果最佳。
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