弯孢霉感染的实验性治疗
Experimental treatment of Curvularia infection.
作者信息
Paredes Katihuska, Capilla Javier, Sutton Deanna A, Mayayo Emilio, Fothergill Annette W, Guarro Josep
机构信息
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, TX, USA.
出版信息
Diagn Microbiol Infect Dis. 2014 Aug;79(4):428-31. doi: 10.1016/j.diagmicrobio.2014.05.004. Epub 2014 May 17.
We have evaluated the efficacy of amphotericin B, posaconazole, and voriconazole in immunosuppressed murine models of disseminated infection by Curvularia spicifera and Curvularia hawaiiensis. The 3 antifungals improved survival of mice in comparison to controls; however, only the 2 azoles were able to reduce significantly the fungal load.
我们评估了两性霉素B、泊沙康唑和伏立康唑在由稻弯孢霉和夏威夷弯孢霉引起的播散性感染免疫抑制小鼠模型中的疗效。与对照组相比，这三种抗真菌药物均提高了小鼠的存活率；然而，只有两种唑类药物能够显著降低真菌负荷。
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