Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Cytokine. 2010 Mar;49(3):264-8. doi: 10.1016/j.cyto.2009.11.006. Epub 2009 Dec 14.
Cytokines play important roles in heart failure (HF). We examined whether cytokine levels are different in acute decompensated heart failure (ADHF) patients between with left ventricular systolic dysfunction (LVSDF) and with preserved LV ejection function (PLVEF). We studied 81 HF patients who were admitted to our hospital with acute decompensation. They were divided into two groups: LVSDF (LVEF)<45% and PLVEF (LVEF45%). Serum interleukin-6 (IL-6), highly sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-alpha), and IL-18 and plasma brain natriuretic peptide (BNP) were measured on admission and at discharge. On admission, IL-6 and hsCRP were higher in LVSDF than in PLVEF. IL-6 and hsCRP decreased after treatment in LVSDF, but not in PLVEF, while plasma BNP levels decreased in both HF with treatment. There was no difference in TNF-alpha or in IL-18 level between LVSDF and PLVEF, and they did not change after treatment in either group. In conclusion, cytokine profiles were different in ADHF between those with LVSDF and PLVEF. Activation of IL-6-hsCRP pathway may play a specific role in ADHF with LVSDF.
细胞因子在心力衰竭（HF）中发挥重要作用。我们研究了左心室收缩功能障碍（LVSDF）和保留左心室射血功能（PLVEF）的急性失代偿性心力衰竭（ADHF）患者的细胞因子水平是否不同。我们研究了 81 例因急性失代偿而入院的 HF 患者。他们被分为两组：LVSDF（LVEF）<45%和 PLVEF（LVEF45%）。入院时和出院时测量血清白细胞介素-6（IL-6）、高敏 C 反应蛋白（hsCRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-18 以及血浆脑钠肽（BNP）。入院时，LVSDF 组的 IL-6 和 hsCRP 高于 PLVEF 组。LVSDF 组治疗后 IL-6 和 hsCRP 降低，但 PLVEF 组无变化，而两组治疗后血浆 BNP 水平均降低。LVSDF 和 PLVEF 之间 TNF-α或 IL-18 水平无差异，且两组治疗后均无变化。总之，ADHF 中 LVSDF 和 PLVEF 之间细胞因子谱不同。IL-6-hsCRP 通路的激活可能在 LVSDF 的 ADHF 中发挥特定作用。
