Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Neuron. 2009 Dec 10;64(5):595-7. doi: 10.1016/j.neuron.2009.11.029.
Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.
活性区是神经递质释放的部位,但它们的组装机制还不太清楚。在本期《神经元》杂志上,Graf 等人在果蝇中进行了一项遗传筛选,并揭示了 Rab3 GTPase 在神经肌肉接头处组织活性区的新作用。