Institute for Biology, Genetics, Freie Universität Berlin, 14195 Berlin, Germany.
Institute for Biology, Genetics, Freie Universität Berlin, 14195 Berlin, Germany
Learn Mem. 2024 Jun 11;31(5). doi: 10.1101/lm.054013.124. Print 2024 May.
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within the mushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.
指导神经元回路中记忆形成和巩固的复杂分子和结构序列在很大程度上仍然难以捉摸。在这项研究中，我们研究了两种关键的突触前调节蛋白的作用，即富含突触小泡的小分子 GTP 酶 Rab3 和细胞粘附蛋白神经连接蛋白-1，它们在蘑菇体 Kenyon 细胞中不同记忆阶段的形成中发挥作用。我们的发现表明，这两种蛋白质在突触前末端的记忆支持过程中都起着至关重要的作用，它们在不同的可塑性模块中发挥作用。这些模块可能包括现有活性区（AZ）的重塑和成熟，以及新 AZ 的形成。
