Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mol Cell. 2009 Dec 11;36(5):715-9. doi: 10.1016/j.molcel.2009.11.030.
The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.
真核生物染色体的线性结构给细胞带来了挑战，因为 DNA“末端”的存在给 DNA 复制机制和细胞的损伤反应系统带来了问题。今年的诺贝尔生理学或医学奖表彰了一些具有开创性的研究，这些研究确立了端粒领域是生物医学研究的一个关键领域。
