The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.
Mol Cell. 2009 Dec 11;36(5):736-42. doi: 10.1016/j.molcel.2009.11.029.
A flurry of recent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in the activation of NF-kappaB by TNF. Here, we integrate these findings into a model for TNF-R1 signaling-and underscore the importance of individual components, including linear ubiquitin chains-which allows for the remarkable versatility of the ubiquitin system.
最近的一系列新发现对泛素依赖性过程如何最终导致 TNF 激活 NF-κB 的现有教条提出了挑战。在这里，我们将这些发现整合到一个 TNF-R1 信号转导模型中，并强调了包括线性泛素链在内的各个组成部分的重要性，这使得泛素系统具有显著的多功能性。
